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The Cardinals square off against the Padres for game one of this three-game series this evening at 7:15 pm.Here are the lineups:
| Cardinals | Padres | ||
| Matt Carpenter | 5 | Travis Jankowski | 8 |
| Tommy Pham | 8 | Eric Hosmer | 4 |
| José Martínez | 3 | Hunter Renfroe | 7 |
| Marcell Ozuna | 7 | Franmil Reyes | 9 |
| Yadier Molina | 2 | Cory Spangenberg | 4 |
| Jedd Gyorko | 4 | Christian Villanueva | 5 |
| Dexter Fowler | 9 | Freddy Galvis | 6 |
| Yairo Muñoz | 6 | Rafael Lopez | 2 |
Jack Flaherty | 1 | Jordan Lyles | 1 |
Cardinals record against the Padres in 2018: 2-2
Cardinals record in the series: 0-0
Cardinals place in the NL Central: 3rd
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