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Carlos Martínez (0-1, 8.31 ERA) of the Cardinals will square off against Jhoulys Chasín (0-0, 10.80 ERA) of the Brewers at Miller Park at 6:40 pm. Here are the lineups:
| Cardinals | Brewers | ||
| Dexter Fowler | 9 | Eric Thames | 3 |
| Tommy Pham | 8 | Christian Yelich | 9 |
| Matt Carpenter | 5 | Lorenzo Cain | 8 |
| Marcell Ozuna | 7 | Travis Shaw | 5 |
| José Martínez | 3 | Domingo Santana | 9 |
| Yadier Molina | 2 | Jonathan Villar | 4 |
| Paul DeJong | 6 | Manny Peña | 2 |
| Kolten Wong | 4 | Eric Sogard | 6 |
| Carlos Martinez | 1 | Jhoulys Chasin | 1 |
Cardinals record against the Brewers in 2018: 1-1
Cardinals record in the series: 1-1
Cardinals place in the NL Central: Tied for 3