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Game one of this best of three against the Reds begins this evening at 7:15 pm. Here are the lineups:
| Cardinals | Reds | ||
| Tommy Pham | 8 | Jesse Winker | 9 |
| Matt Carpenter | 4 | Jose Peraza | 6 |
| Jose Martínez | 3 | Joey Votto | 3 |
| Marcell Ozuna | 7 | Scooter Gennett | 4 |
| Yadier Molina | 2 | Adam Duvall | 7 |
| Jedd Gyorko | 5 | Tucker Barnhart | 2 |
| Harrison Bader | 9 | Alex Blandino | 5 |
| Paul DeJong | 6 | Brandon Finnegan | 1 |
| Michael Wacha | 1 | Billy Hamilton | 8 |
Cardinals record against the Reds in 2018: 4-0
Cardinals record in the series: 0-0
Cardinals place in the NL Central: 2nd