The only pitchers who debuted in the expansion era with that many wins against one team are Steve Carlton (41 wins against the Cubs, 39 vs. the Pirates and 38 vs. the Cardinals),Greg Maddux (35 vs Mets) and Don Sutton (35 against the Braves).

38 victories against the Cardinals, eh?  It still drives me up a wall every time I think about the possibilities of him staying in St. Louis.  For one thing, they'd have had 38 more wins!